Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.7, p.504–511,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.121, No.7, p.504–511,2020

Title: Histological, immunohistochemical and biochemical effects of bee bread on stomach tissue of obese rats
Author: Z. Doganyigit, B. Yakan, M. Soylu, E. Kaymak, A. Okan, S. Silici

Abstract: Obesity is a major health problem threatening humanity in medical, social and psychological dimensions. In this study, we aimed to determine the histological, immunohistochemical and biochemical effects of bee bread, added to diets of obese rats in different doses, on leptin and ghrelin expression. In the study, 40 female Sprague‒Dawley (200‒250 g) rats were randomly divided into 5 equal groups and then assigned to control and obesity groups. The obesity group consisted of four subgroups: high‑fat diet group, 100 and 200 mg/kg/bw groups, and metformin group. Histopathological evaluation revealed structural deterioration and necrotic areas in the epithelium and glands of the obese rats’ stomach tissue, while in their serum and gastric tissues, the MDA level was significantly higher than in the other groups. There was a negative correlation between leptin and ghrelin levels. Apoptotic cells increased with obesity, but the application of beebread was similarly effective as metformin administration in reducing this increase (Tab. 5, Fig. 4, Ref. 51).

Keywords: bee bread, leptin, ghrelin, stomach, obesity, rat
Published online: 25-Jun-2020
Year: 2020, Volume: 121, Issue: 7 Page From: 504, Page To: 511

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