Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.7, p.516–521,2020

Journal info


 


Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

Aims and Scope
Editorial Info
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Bratislava Medical Journal Vol.121, No.7, p.516–521,2020

Title: The relation of left internal mammary artery atherosclerosis with urotensin-II
Author: L. Bahar, M. E. Tuysuz

Abstract: BACKGROUND: The aim of our study is to investigate the effects of urotensin-II (U-II) on the left internal mammary artery (LIMA) wall and role of U-II in atherosclerotic processes affecting the long-term patency of LIMA.
METHOD: Patients were divided into 2 groups, namely Group I: patients with coronary artery disease (CAD) and Group II: DM + CAD. The patients were evaluated by Gencini scoring before coronary artery bypass grafting (CABG). Routine tissue follow-up, hemotoxylin-eosin staining and immunoreactivity with U-II were observed. Then, vessel damage score, H-Score and LIMA layer thickness were calculated and evaluated statistically.
RESULTS: On light microscopic examination, the LIMA total damage score in DM + CAD group was significantly higher compared to the control group. The assessment of H score revealed that U-II was more intense in tunica intima and tunica media in the DM+CAD group as compared to the control group (p < 0.05). Furthermore, tunica intima and tunica media in the DM + CAD group were thicker than in the control group (p < 0.05).
CONCLUSIONS: We found that U-II is effective in atherosclerotic processes of arterial grafts. The DM + CAD group has high U-II density with high total damage score in intima and media layers of LIMA. U-II may be effective in late survival results after CABG (Tab. 3, Fig. 2, Ref. 19).

Keywords: coronary artery disease, left internal mammary artery, atherosclerosis. urotensin II, diabetes mellitus
Published online: 25-Jun-2020
Year: 2020, Volume: 121, Issue: 7 Page From: 516, Page To: 521
doi:10.4149/BLL_2020_085


download file



© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.