Home HOME Neoplasma 2020 Neoplasma Vol.67, No.5, p.1122–1130, 2020

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ISSN 0028-2685
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Neoplasma Vol.67, No.5, p.1122–1130, 2020

Title: miR-497 inhibits tumor growth and migration of osteosarcoma by targeting plexinA4 and CDK6
Author: Z. S. Tian, M. J. Yan, S. Li, D. Cong, Y. Y. Wang, Q. S. Zhu



MicroRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level which have been reported to be involved in the pathogenesis of various cancers. In the present study, we found that miR-497 was downregulated in osteosarcoma tissues. Gain and loss of function studies were carried out to investigate the effect of miR-497 on the growth of osteosarcoma cells. The results indicated that miR-497 inhibited the growth of osteosarcoma cells. Furthermore, bioinformatics analysis predicted plexinA4 and CDK6 as targets of miR-497, which was afterward confirmed by luciferase activity assay and rescue experiments. These findings suggested that miR-497, plexinA4, and CDK6 may serve as novel potential makers for osteosarcoma diagnostics and therapy.


Retraction in https://doi.org/10.4149/neo_2022_200108N26R

Keywords: miR-497, plexinA4, CDK6, osteosarcoma
Published online: 01-Jul-2020
Year: 2020, Volume: 67, Issue: 5 Page From: 1122, Page To: 1130

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