Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.8, p.554–557,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.121, No.8, p.554–557,2020

Title: The role of miRNAs targeting K-ras and APC genes in colorectal cancer
Author: N. Yilmaz, U. Yilmaz, K. Tanbek, S. Arikan, N. Aksakal, U. Zeybek, A. Ergen

Abstract: OBJECTIVES: The occurrence of abnormal expression patterns in different types of cancer suggests that micro RNAs (miRNAs) may play an important role in tumorigenesis. The aim of this study was to examine the expression levels of miRNAs known to be associated with the regulation of the expression levels of the APC and K-ras, which are important in the development of colorectal cancer (CRC).
METHODS: The expression levels of miR-27, miR-663, miR-217, miR-181d, APC and K-ras in the serum, tumor and adjacent tumor-free (healthy) tissues of the patients and serum of the healthy controls were investigated with qRT-PCR.
RESULTS: Expression levels of miR-217, mR-181d, miR-663, miR-27 and K-ras were found to be higher in CRC tissues than in adjacent tumor-free tissues of the patients. In patient serum samples, miR-663 levels were statistically more elevated than in controls. In patient tumor tissues, miR-217, miR-181d and miR-27 expressions were found to be higher.
CONCLUSIONS: Increased miR-181d and miR-217 expression levels are associated with increased K-ras expression in the tumor tissues, and the expression of K-ras, which takes part as an oncogene in the CRC development, might be regulated by these miRNAs (Tab. 4, Ref. 33).

Keywords: colorectal, cancer, miRNA, APC, K-ras
Published online: 28-Jul-2020
Year: 2020, Volume: 121, Issue: 8 Page From: 554, Page To: 557

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