Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.8, p.565–570,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.121, No.8, p.565–570,2020

Title: Effectiveness of myo-inositol oxygenase in the early diagnosis of experimental acute kidney injury
Author: C. Mertoglu, Z. C. Ozmen, F. Firat, A. Arici, V. Unsal, F. Erdemir

Abstract: OBJECTIVES: The effectiveness of the myo-inositol oxygenase (MIOX) enzyme was investigated in the diagnosis of acute kidney injury (AKI).
METHODS: In total, 40 rats were divided into 5 groups (n = 8, for each group) while left kidney ischemia-reperfusion was implemented in groups 2, 3, 4 and 5. Group 1 was the control group. Group 2 underwent 1‑hour ischemia and 2‑hour reperfusion. Group 3 underwent 1‑hour ischemia and 4‑hour reperfusion. Group 4 underwent 2‑hour ischemia and 2‑hour reperfusion. Group 5 underwent 2‑hour ischemia and 4‑hour reperfusion.
RESULTS: Serum creatinine and blood urea nitrogen levels in all ischemia-reperfusion groups were higher than in the control group (p<0.001). Serum MIOX level was higher in groups 2, 3 and 4 than in group 1
(p=0.002). Tissue MIOX level was lower in groups 2, 4, and 5 than in group 1 (p=0.039). Serum and tissue neutrophil gelatinase-associated lipocalin levels were not significantly different between the groups. The injury level in histopathologic examination was as follows: group 1CONCLUSION: The serum MIOX level increases in the early stages of AKI, however, decreases subsequently. Therefore, the serum MIOX may be a potential promising biomarker in the early diagnosis of AKI (Tab. 5, Fig. 6, Ref. 30).

Keywords: renal ischemia-reperfusion; myo-inositol oxygenase; acute kidney injury; diagnostic biomarker; neutrophil gelatinase- associated lipocalin
Published online: 28-Jul-2020
Year: 2020, Volume: 121, Issue: 8 Page From: 565, Page To: 570
doi:10.4149/BLL_2020_094


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