Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.8, p.571–579,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.121, No.8, p.571–579,2020

Title: Recombinant human MMP-2 associated with monoolein improves bone repair
Author: F A. T. de Figueiredo, J. P. Azevedo, M. G. Lara, C. A. Meschiari, J. P. M. Issa, R. F. Gerlach, T. C. L. Lamano

Abstract: OBJECTIVE: The main objective of the present study was to investigate the possible osteostimulatory action of recombinant human matrix metalloproteinase-2 (rhMMP-2) implanted in a bone defect made in calvaria of rats, bounded to the monoolein as carrier.
METHODS: Forty-four adult male Wistar rats (about 600 g body weight) underwent surgery in order to create a spherical defect in parietal bone on the right side of the median sagittal suture by using 4 mm diameter of a trephine drill. Animals were divided into three groups: no treatment (control, C), treatment with rhMMP-2 diluted in monoolein liquid crystal (rhMMP-2) and negative control with monoolein (M). The groups were divided into two experimental times, 2- and 4-weeks of experimental time.
RESULTS: The rate of new-formed bone, estimated by the number of points on new-formed cancellous bone, was in enhanced rhMMP-2 group in both periods in comparison to C or M groups.
CONCLUSION: There was no difference in bone neoformation between second to fourth week within groups. In the present study, monoolein alone had a negative role in the post-operative surgery, but monoolein associated with +rhMMP-2 had a positive role on releasing rhMMP-2 and enhance the rate of new-formed bone (Tab. 1, Fig. 5, Ref. 71).

Keywords: bone, bone defect, monoolein, rhMMP-2, biomaterial
Published online: 28-Jul-2020
Year: 2020, Volume: 121, Issue: 8 Page From: 571, Page To: 579

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