Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Neoplasma Vol.67, No.6, p.1214–1222, 2020 |
||
Title: The significance of Siglec-15 expression in resectable non-small cell lung cancer | ||
Author: J. Q. HAO, J. Y. NONG, D. ZHAO, H. Y. LI, D. SU, L. J. ZHOU, Y. J. DONG, C. ZHANG, N. Y. CHE, S. C. ZHANG, J. Z. LIN, J. B. YANG, H. T. ZHANG, J. H. WANG | ||
Abstract: Siglec-15 (S15) is another important mechanism of tumor immune escape besides the PD-L1/PD-1 pathway and represents a new kind of immune checkpoint inhibitor. However, the associations of tumor Siglec-15 expression with clinicopathological characteristics and outcomes of non-small cell lung cancer (NSCLC), and tumor-infiltrating lymphocytes (TILs) in a tumor microenvironment (TME) have so far been unclear. A total of 324 NSCLC surgical samples on tumor microarray were used in this study for investigating the association of S15 expression with clinicopathological characteristics and overall survival (OS) as well as correlation with TILs using multiplex immunofluorescence staining and PD-L1. Results showed that the expression of S15 in adenocarcinoma was significantly higher than that in squamous cell carcinoma. S15 expression was positively correlated with CD8+ T cell density in the stroma. The expression rate of PD-L1 in lung squamous cell carcinoma was higher than that in lung adenocarcinoma. S15 expression was not associated with the prognosis of early NSCLC. The pathological mechanism of the co-expression of S15 and PD-L1 in resectable NSCLC remains to be further studied. |
||
Keywords: NSCLC; Siglec-15; TILs; multiplex immunofluorescence staining | ||
Published online: 04-Aug-2020 | ||
Year: 2020, Volume: 67, Issue: 6 | Page From: 1204, Page To: 1222 | |
doi:10.4149/neo_2020_200220N161 |
||
|
download file |
|