Home Acta Virologica 2020 Acta Virologica Vol.64, No.3, p.297-306, 2020

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.64, No.3, p.297-306, 2020

Title: MicroRNA-185 reduces the expression of hepatitis B virus surface antigen by targeting PRKCH in HepG2 2.2.15 cells
Author: R. Zhang, Z. Liu, X. Hou, M. Wang, Y. Xiong, H. Lu, Y. Wang, J. Su, Y. Liu, G. Zhang, Y. Liu

Abstract: MicroRNAs (miRNAs) are single-stranded noncoding RNAs with 18 to 25 nucleotides and play critical roles in a wide spectrum of biological processes. We repored that miR-185 inhibited hepatitis B surface antigen (HBsAg) expression and hepatitis B virus (HBV) replication without affecting the proliferation of HepG2 2.2.15 cells, compared with the controls. We identified that protein kinase C eta (PRKCH) is a direct target gene of miR-185 that affects HBV replication and protein expression and that the miR-185 may suppress HBV replication. Our results provide more information for gene therapy in HBV infection.

Keywords: miR-185; HBV; HBV surface antigen; viral replication; PRKCH
Published online: 10-Aug-2020
Year: 2020, Volume: 64, Issue: 3 Page From: 297, Page To: 306

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