Home HOME General Physiology and Biophysics 2020 General Physiology and Biophysics Vol.39, No.4, p.363–371, 2020

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.39, No.4, p.363–371, 2020

Title: Down-regulation of RFWD3 inhibits cancer cells proliferation and migration in gastric carcinoma
Author: Jia Jia, Yanguo Yang, Tingting Yan, Tao Chen, Guangxin Lu

Abstract: The E3 ligase RING finger and WD repeat domain 3 (RFWD3) can stabilize p53 in response to DNA damage, participate in replication checkpoint, and have an important role in multiple myeloma, testicular germ cell tumor and lung carcinogenesis. Its expression and molecular mechanisms have never been explored in gastric cancer. In present study, the RFWD3 was found over-expressed in the both AGS and HGC-27 gastric cancer cells. Knockdown of RFWD3 suppressed cells proliferation activity of gastric cancer cells. Further study showed that the down-regulation of RFWD3 promotes cell apoptosis, suppresses cell migration and invasion and blocks G2/M cell cycle progression, which may be related with AKT, ERK/P38 and Slug pathways. In summary, the results of the present study showed that RFWD3 might be an oncogene candidate for gastric cell proliferation and may have an important role in gastric carcinogenesis.

Keywords: RFWD3 — Gastric carcinoma — Cell proliferation — Cell migration
Published online: 18-Aug-2020
Year: 2020, Volume: 39, Issue: 4 Page From: 363, Page To: 371

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