Home HOME Neoplasma 2021 Neoplasma Vol.68, No.1, p.79–86, 2021

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.68, No.1, p.79–86, 2021

Title: Cancer-associated fibroblasts promote cell proliferation and invasion via paracrine Wnt/IL1β signaling pathway in human bladder cancer
Author: Fan Yang, Zhuifeng Guo, Chang He, Liang Qing, Hang Wang, Jiawen Wu, Xuwei Lu

Abstract: Bladder cancer (BC) is the most common urinary system malignancy worldwide. However, the molecular mechanisms underlying its progression remain largely unexplored. Accumulating evidence indicates that the cancer-associated fibroblasts (CAFs), major constituents of tumor stroma, play a key role in tumor development. Herein, we have successfully isolated CAFs and paired normal fibroblasts (NFs) from bladder cancer tissues. We observed that the conditional medium from bladder cancer (CM-CAF) could significantly enhance cell proliferation (P IL1β signaling feedback to enhance the aggressive phenotype of bladder cancer cells. In addition, we treated T24 cells with CM-CAF alone, or together with Wnt signaling inhibitor XAV939. We found that the inhibition of Wnt signaling could sufficiently abolish the oncogenic effect of CAFs on bladder cancer. In conclusion, our data revealed a novel mechanism that CAFs promote cell proliferation and invasion of human BC cells through Wnt/IL1β signaling feedback. Inhibition of the Wnt signaling pathway may provide a promising target to block the interaction between CAF and bladder cancer cells.

Keywords: bladder cancer; cancer associated fibroblast; IL1β; Wnt; cell proliferation; invasion
Published online: 27-Aug-2020
Year: 2021, Volume: 68, Issue: 1 Page From: 79, Page To: 86

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