Home HOME Neoplasma 2021 Neoplasma Vol.68, No.1, p.200–207, 2021

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.68, No.1, p.200–207, 2021

Title: Long-term clinical benefit of Peg-IFNα and NAs sequential anti-viral therapy on HBV related HCC
Author: Wen-Qian Qi, Qian Zhang, Xu Wang, Yan Xu, Ping Zhao, Hong-Hua Guo, Chang-Yu Zhou, Yu Sun, Lin Liu, Jiang-Bin Wang

Abstract: Analysis of the value of long-term anti-viral therapy using sequential Peg-IFN therapy and nucleos(t)ide analogues (NAs) improves the prognosis of HBV-related HCC. HBV-related HCC patients were classified into sequential therapy with Peg-IFNα-2a and NAs, and NAs therapy alone. All patients were followed up for 5 years. The survival rate, HCC recurrence rate, Child Pugh score, and side effects of drugs were evaluated. Firstly, the early and late cumulative survival rate was higher in patients receiving antiviral therapy compared with the control patients (P < 0.05).
Patients receiving sequential therapy with Peg-IFNα-2a and NAs showed a higher late cumulative survival rate and significantly reduced early and late recurrence rate, compared to those in the NA-alone group (P < 0.05). Single NAs therapy only reduced the late recurrence rate in HCC-patients. Secondly, NAs therapy significantly increased the Child Pugh score after five years of therapy (five-year therapy 7.03 ± 1.50 vs. initial score 6.63 ± 0.85; P 0.05).
Compared to the control patients, patients receiving anti-viral therapy (NAs alone or sequential therapy with Peg-IFNα-2a and NAs) exhibited a significantly decreased Child Pugh score (P recurrence rate in patients.

Keywords: primary hepatocellular carcinoma; Peg-IFN; nucleos(t)ide analogues; antiviral therapy
Published online: 17-Sep-2020
Year: 2021, Volume: 68, Issue: 1 Page From: 200, Page To: 207

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