Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.10, p.700–704,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.121, No.10, p.700–704,2020

Title: MicroRNA and hyperaggregability of platelets in women with sticky platelet syndrome and pregnancy complications
Author: L. Vadelova, M. Skerenova, J. Ivankova, A. Vazanova, J. Sokol, J. Zolkova, L. Stanciakova, I. Skornova, J. Stasko

Abstract: AIMS: We aimed to characterize relationship between the expression profiles of platelet miR-96, miR-126 and miR-223 and platelet function examination in patients with sticky platelet syndrome (SPS) and in healthy controls.
BACKGROUND: MicroRNAs (miRNA, miR) are a group of small and non-coding RNAs involved in many mechanisms as regulators of post-transcriptional protein expression in platelets. SPS is defined as platelet hyperaggregability after administration of low doses of adenosine diphosphate and/or epinephrine. Clear genetic abnormality of this syndrome is not known yet.
METHODS: We examined 45 patients with SPS and 30 healthy volunteers. For functional platelet examination we used light transmission aggregometry, and qRT-PCR was used to determine the expression of the miRNAs.
RESULTS: We observed no relationship of the platelet miRNA expression with functional platelet examination in the entire cohort of patients with SPS. However, in a group of patients with SPS and pregnancy complications, we found that the expression of platelet miR-96 (p = 0.009) was up-regulated.
CONCLUSION: In spite of the multiple limitations of the study, it can be considered that the increased expression of platelet miR-96 found in a group of patients with SPS and pregnancy complications could be related to the hyperaggregability in these selected patients (Tab. 2, Ref. 31).

Keywords: sticky platelet syndrome, platelet miRNA, platelet hyperaggregability, magnetic platelet separation
Published online: 20-Sep-2020
Year: 2020, Volume: 121, Issue: 10 Page From: 700, Page To: 704
doi:10.4149/BLL_2020_114


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