Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.10, p.749–752,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.121, No.10, p.749–752,2020

Title: Zinc and melatonin supplementation ameliorates brain cortex tissue damage in DMBA-induced breast cancer in rats
Author: E. Gulbahce Mutlu, S. B. Baltaci

Abstract: BACKGROUND: This study aims to investigate the effects of zinc and melatonin supplementation on lipid peroxidation in the brain cortex in DMBA-induced breast cancer in female rats.
METHODS: A total of 42 recently weaned Wistar rats were divided into 5 groups as follows: Control (Group 1), DMBA Control (Group 2), DMBA+Zinc (Group 3), DMBA+Melatonin (Group 4), DMBA+Melatonin et Zinc (Group 5). At the end of the study, all animals were sacrificed by decapitation and Malondialdehyde (MDA) and glutathione (GSH) levels in brain cortex tissue samples were determined via spectrophotometric methods.
RESULTS: The highest MDA levels were in the DMBA-treated group (Group 2) (p<0.05). MDA levels in Group 3, Group 4, and Group 5 were significantly lower than in group 2 (p<0.05). Also, GSH levels in group 3, 4, and 5 were significantly higher than in group 2 (p<0.05).
CONCLUSION: There are no reports on whether DMBA-induced experimental breast cancer affects oxidative stress in brain tissue. In this respect, our study revealed that the increased brain cortex tissue damage in DMBA-induced breast cancer is alleviated by Zinc, melatonin, or combined zinc and melatonin treatment (Fig. 3, Ref. 26).

Keywords: DMBA, breast cancer, brain tissue, MDA, GSH, zinc, melatonin
Published online: 20-Sep-2020
Year: 2020, Volume: 121, Issue: 10 Page From: 749, Page To: 752
doi:10.4149/BLL_2020_122


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