Acta Virologica Vol.64, No.3, p.352-358, 2020

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.64, No.3, p.352-358, 2020
Title: In the peripheral blood mononuclear cells (PBMCs) of HCV infected patients the expression of STAT1 and IRF-1 is downregulated while that of caspase-3 upregulated
Author: A. Alhetheel, A. Albarrag, A. Hakami, Z. Shakoor, K. Alswat, A. Abdo, W. Al-Hamoudi, S. Alomar

Abstract: Several peripheral blood mononuclear cell (PBMC) defects have been linked with hepatitis C virus (HCV) infection, including alterations in cytokine secretion and increased cell death. This study was performed to investigate the expression levels of signal transducer and activator of transcription 1 (STAT1), interferon regulatory factor 1 (IRF-1), and caspase 3 in PBMCs of patients infected with HCV. STAT1, IRF-1, and caspase 3 expression levels were compared in PBMCs from 19 untreated (naïve) HCV+ patients, 8 treated (sustained responder [SR]) HCV patients, and 20 HCV– healthy controls. Moreover, PBMCs from naïve HCV+ patients and SR-HCV patients were also evaluated for HCV RNA expression. The expression levels of STAT-1 and IRF-1 were significantly downregulated in PBMCs from naïve HCV+ patients (P

Keywords: PBMC; hepatitis C virus; STAT1; IRF-1; caspase-3
	Published online: 21-Sep-2020
Year: 2020, Volume: 64, Issue: 3	Page From: 352, Page To: 358
doi:10.4149/av_2020_313
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