Home HOME Neoplasma 2021 Neoplasma Vol.68, No.1, p.23–30, 2021

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.68, No.1, p.23–30, 2021

Title: Homeobox C4 promotes hepatocellular carcinoma progression by the transactivation of Snail
Author: Tao Yang, Xian-Bo Zhang, Xiao-Na Li, Ming-Ze Sun, Peng-Zhi Gao

Abstract: Homeobox C4 (HOXC4) belongs to the homeoprotein family of transcription factors, which play a critical role in morphogenesis and differentiation during embryonic development. Aberrant expression of HOXC4 has been reported in several types of cancers. However, the role of HOXC4 in hepatocellular carcinoma (HCC) remains unknown. Here, we reported that HOXC4 is upregulated in HCC tissues and predicts a poor outcome in patients with HCC. HOXC4 promotes HCC progression and induces an EMT-like phenotype both in vitro and in vivo. Furthermore, we demonstrated that the EMT-related transcription factor Snail is a transcriptional target of HOXC4 and HOXC4 regulates EMT by regulation of transforming growth factor β (TGF-β) signaling in HCC. Together, our study suggests that HOXC4 as a novel potential therapeutic target for HCC therapy.

Keywords: HOXC4; Snail; TGF-β; epithelial-mesenchymal transition; hepatocellular carcinoma
Published online: 25-Sep-2020
Year: 2021, Volume: 68, Issue: 1 Page From: 23, Page To: 30

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