Home Neoplasma 2021 Neoplasma Vol.68, No.1, p.154–164, 2021

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Neoplasma Vol.68, No.1, p.154–164, 2021

Title: Differential profiling of prostate tumors versus benign prostatic tissues by using a 2DE-MALDI-TOF-based proteomic approach
Author: Monika Kmeťová Sivoňová, Zuzana Tatarková, Jana Jurečeková, Ján Kliment, Márk Híveš, Lucia Lichardusová, Peter Kaplán

Abstract: Oncoproteomic technologies offer a complementary approach to the understanding of cancer proteins' function and the translation of molecular knowledge into clinical practice. Our aim was to compare the proteomic profiles of prostate tumors versus benign prostatic hyperplasia (BPH) tissues in order to identify modulated proteins as the potential biomarkers for prostate cancer. Proteins extracted from twenty prostate cancer tissue specimens and ten BPH tissues were analyzed by two-dimensional electrophoresis (2-DE) coupled with MALDI-TOF mass spectrometry. Western blot and quantitative real-time PCR (RT-PCR) were performed to confirm the different amount of protein biomarkers revealed by 2DE combined with MALDI mass spectrometry. We found 42 spots whose expression in the prostate was altered more than 1.5-fold compared with BPH tissue (p

Keywords: proteomics; prostate cancer; mass spectrometry; protein expression; cytoskeleton
Published online: 25-Sep-2020
Year: 2021, Volume: 68, Issue: 1 Page From: 154, Page To: 164
doi:10.4149/neo_2020_200611N625
Price: 26.40 €






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