Home HOME Neoplasma 2021 Neoplasma Vol.68, No.2, p.375–381, 2021

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Neoplasma Vol.68, No.2, p.375–381, 2021

Title: Impact of HBV infection on the association between HOTAIR SNPs and the risk of hepatocellular carcinoma: A mediation and interaction analysis
Author: Jinqun Cheng, Guiyan Liu, Junguo Zhang, Qing Liu, Zhifeng Lin, Nana Tian, Xinqi Lin, Li Liu, Xinfa Yu, Yanhui Gao

Abstract: Previous studies have demonstrated that single nucleotide polymorphisms (SNPs) rs12427129 and rs3816153 in HOX transcript antisense intergenic RNA (HOTAIR) might interact with hepatitis B virus (HBV) infection to increase the risk of hepatocellular carcinoma (HCC). However, it is unclear whether HBV infection is a potential mediator between HOTAIR rs12427129, rs3816153, and HCC. This study, including 1262 HCC cases and 1559 controls, aimed to use a four-way decomposition method to quantify the interaction and mediation effects of HBV infection in the association between rs12427129, rs3816153, and HCC. We found that rs12427129 and rs3816153 were associated with a risk of HBV infection among the controls (CC: CT + TT, adjusted odds ratio (OR) = 1.77, 95% confidence interval (CI) = 1.32-2.36 and GG: GT + TT, adjusted OR = 0.63, 95% CI=0.48-0.82).
The four-way decomposition revealed that rs12427129, rs3816153 and HBV infection had statistically significant reference interaction on HCC (excess risk (95% CI): -0.362 (-0.530, -0.195), P gested that the rs3816153 GT + TT genotype can reduce the risk of HCC by 21.79% (excess risk (95% CI): -0.075 (-0.142, -0.009), P = 0.026) when HBV infection as a mediator. Our findings suggested that HBV infection interacts or mediates with the association between rs12427129, rs3816153, and HCC. This would provide a new perspective for exploring the underlying biological mechanism between HOTAIR SNPs, HBV infection, and HCC.

Keywords: hepatitis B virus; single nucleotide polymorphisms; hepatocellular carcinoma; four-way decomposition method
Published online: 23-Oct-2020
Year: 2021, Volume: 68, Issue: 2 Page From: 375, Page To: 381

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