Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.11, p.786–788,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.121, No.11, p.786–788,2020

Title: Glucose-6-phosphate dehydrogenase deficiency enhances Covid-19 infection in elderly people
Author: S. M. N. Abdel Hafez

Abstract: Our understanding of the mechanisms responsible for death of aged people from Covid-19 became one of the major concerns of these days. Glucose-6-phosphate dehydrogenase (G6PD) enhances the normal senescence and accelerates the precocious removal of chronologically young, yet biologically aged cells. Thus, its deficiency is associated with an increase in the cellular oxidative stress. Accumulating evidence showed that oxidative stress has a fundamental role in several age-related diseases. Nowadays, Covid-19 is considered a serious health problem worldwide. The host cellular environment is the key determinant of pathogen Infectivity. Most respiratory viral infections have a strong association with Glucose-6-phosphate dehydrogenase. Unfortunately, this enzyme deficiency markedly decreases with aging what is involved in increasing of the morbidity rate. The aim of this mini review was to shed more light on the role of G6PD deficiency in aged people infected with Covid-19 (Ref. 20).

Keywords: GSPD, Covid-19, elderly people
Published online: 09-Nov-2020
Year: 2020, Volume: 121, Issue: 11 Page From: 786, Page To: 788

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