Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.11, p.789–795,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.121, No.11, p.789–795,2020

Title: Evaluation of the neuroprotective efficiency of sodium hydrosulfide in neonatal rats with the induced hypoxic-ischemic encephalopathy model
Author: B. Cebeci, E. E. Yalinbas, R. Akcilar, H. Metineren

Abstract: AIMS: Hypoxic ischemic encephalopathy is one of the main causes of neonatal deaths.
The objective of this study was to evaluate the neuroprotective effect of antioxidant and anti-inflammatory properties of sodium hydrosulfide (NaHS) in neonatal rats with hypoxic ischemic encephalopathy, as well as its effect on neuronal apoptosis through histopathological and biochemical tests.
METHODS: Forty-seven-day‑old rats with induced hypoxia‑ischemia (HI) were randomly separated into four groups. Half an hour after the induction of hypoxic-ischemia, serum physiological (SF), 50 µmol/kg NaHS, or 100 µmol/kg NaHS were intraperitoneally given to the rats.
RESULTS: Apoptotic cells in the brain tissue of rats in HI + NaHS 50 μmol/kg, and HI + NaHS 100 μmol/kg groups decreased compared to HI group (p = 0.00). While HI + NaHS 50 μmol/kg and HI + NaHS 100 μmol/kg groups yielded no difference in TNF-α, IL-6, and iNOS levels as compared to the HI group, an increase in NGF was detected in the 50 µmol/kg and 100 µmol/kg NaHS groups (p = 0.34, p = 0.24, p = 0.26, p = 0.026, p = 0.017). When TOS, TAS and OSI levels were compared, an increase in TAS and OSI and a decrease in TOS were observed in the treatment groups as compared to HI group.
CONCLUSIONS: NaHS given to hypoxic-ischemic encephalopathy model significantly decreased apoptosis in neurons and had a neuroprotective efficacy with an increase in NGF levels (Tab. 1, Fig. 3, Ref. 25).

Keywords: hypoxic-ischemic encephalopathy, neonatal, NaHS, NGF, antioxidant
Published online: 09-Nov-2020
Year: 2020, Volume: 121, Issue: 11 Page From: 789, Page To: 795
doi:10.4149/BLL_2020_129


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