Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.11, p.801–804,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.121, No.11, p.801–804,2020

Title: The impact of propranolol on apoptosis in cutaneous squamous cell carcinomas
Author: E. Celik, H. M. Kaplan, E. Singirik

Abstract: OBJECTIVES: Cutaneous squamous cell carcinoma (cSCC) is a common cancer in Caucasian populations. Treatments registered for high-risk cSCC are still undetermined. Experimental data have demonstrated possibly useful effects of a combined application of beta‑blockers in cancer therapy. The goal of this study was to examine the efficacy of propranolol in the treatment of cSCC and its impact on apoptosis. Thus, we aimed to investigate the apoptotic pathway protein levels and activity in beta‑blocker‑treated cSCC cells.
MATERIALS AND METHODS: The study was performed on human cSCC cancer cell line culture. One of the cSCC cell lines was treated with propranolol, whereas no treatment was given to the other group. Then, the levels of apoptotic pathway proteins were determined by ELISA test in both groups.
RESULTS: The propranolol treatment group exhibited a remarkable difference as compared with the other group. It was found that propranolol treatment enhanced the activity of caspase-3 while the expression of bax, wee1, gadd153, grp78 and AIF decreased bcl-2 which is antiapoptotic protein in cSCC cell lines.
CONCLUSION: Our results suggest that propranolol treatment has anti-cancer properties with an effect on various apoptotic pathways in cSCC. These data are important because propronalol may be involved in future cSCC treatment (Tab. 1, Fig. 3, Ref. 22).

Keywords: beta‑blocker, propranolol, cutaneous squamous cell carcinoma, apoptotic pathway
Published online: 09-Nov-2020
Year: 2020, Volume: 121, Issue: 11 Page From: 801, Page To: 804
doi:10.4149/BLL_2020_131


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