Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.12, p.881–887,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.121, No.12, p.881–887,2020

Title: Adrenomedullin and non-dipping circadian pattern in newly diagnosed essential hypertension
Author: O. Yucel, H. Gunes, M. Kerkutluoglu, B. Ozturk, M. Kirisci, F. Baylan Alkan

Abstract: OBJECTIVE: There is frequently a relationship between nocturnal hypertension and non-dipping pattern and endothelial dysfunction. Studies conducted previously have indicated that adrenomedullin (AM) (a potent, long-lasting, vasodilatory peptide) is capable of regulating endothelial cell function. The aim of the current research is to investigate the association between absolute night-time blood pressure (BP) and circadian BP pat­tern with serum AM and high-sensitivity C-reactive protein (hsCRP) levels in cases in whom untreated arterial hypertension has been newly diagnosed.
METHODS: Ambulatory BP monitoring was performed in 100 individuals with hypertension (50 dippers,
50 non-dippers) and 50 healthy controls for 24 hours. Measurement and recording of AM and hsCRP
serum levels were performed.
RESULTS: A strong correlation between night-time BP levels and AM and hsCRP levels was determined
(p<0.001). On the contrary, higher AM levels were determined in the non-dipper group compared to the dipper and normotensive groups (non-dipper group, 258±27 pg/mL; dipper group, 199±30 pg/mL; normotensive group, 150±11 pg/mL; p<0.001). The non-dipper group exhibited significantly higher hsCRP levels in comparison with the remaining two groups (p=0.017). An independent association was determined between AM (p=0.014) and hsCRP (p=0.032) and a non-dipping pattern in a multivariate logistic regression analysis.
CONCLUSIONS: The nocturnal hypertensive and non-dipper groups exhibited increased AM levels. An independent association was identified between AM and hsCRP and a non-dipping pattern. It is implied that increased AM levels in individuals with non-dipper hypertension may be related to a longer exposure time to high BP. The mentioned findings indicate a potential future part of AM in identifying patients with hypertension that are at higher risk of target organ damage (Tab. 3, Fig. 4, Ref. 41).

Keywords: adrenomedullin, high-sensitivity C-reactive protein, dipper, non-dipper hypertension
Published online: 09-Dec-2020
Year: 2020, Volume: 121, Issue: 12 Page From: 881, Page To: 887
doi:10.4149/BLL_2020_145


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