Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.12, p.901–906,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.121, No.12, p.901–906,2020

Title: Characterization of G protein β subunit expression of human brain Glioma tumor
Author: M. Pooladi, M. Entezari, M. Hashemi

Abstract: Proteome indicates the protein content of a genome. Proteome analysis is effective in a new system formulation and prediction, prevention, and treatment based on protein. One of the purposes of proteomics researches is to know and understand the cancer mechanism. In this study, we separated the proteins by the Two-Dimensional Electrophorese method and analyzed and compared protein spots by statistical and software data. The spots were separated and identified by the proteins’ Isoelectric PH differences, molecular weights, and data bank. In continuation, the protein profiles were clustered by MALDI-TOF-TOF and the main element was identified and confirmed. We have used site PhosphoSitePlus® to review post-translational modifications. The findings indicated that the G protein Beta subunit rate increased in the astrocytoma, oligodendroglia, and glioblastoma cerebral malignant tumors. The βγ complex formation may prevent and activates many paths of cellular growth. The βγ complex activity control of the changes after the conversion parallel to GTPase activity of this α subunit may be a formulation mechanism for the G signal path (Tab. 5, Fig. 4, Diagram 2, Ref. 29).

Keywords: glioma, G protein β subunit, proteomics
Published online: 09-Dec-2020
Year: 2020, Volume: 121, Issue: 12 Page From: 901, Page To: 906
doi:10.4149/BLL_2020_148


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