Home Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.1, p.45–48,2021

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.122, No.1, p.45–48,2021

Title: Systemic inflammation in both open-angle and angle-closure glaucoma: role of platelet-to-lymphocyte ratio
Author: M. Karahan, D. Kilic, S. Guven

Abstract: AIM: To analyse the effect of systemic inflammatory status in patients with primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) by calculating platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR).
METHODS: This retrospective case-control study included 200 patients with POAG, 22 patients with PACG and 100 healthy subjects. The participants’ white-blood-cell, lymphocyte, neutrophil, and platelet counts were recorded from previous blood assays. NLR and PLR were calculated manually. Results were compared among the groups.
RESULTS: Both the POAG and PACG groups had higher platelet counts and PLR values than the control group (p=0.001 and p=0.001; respectively). The difference in NLR between POAG, PACG and control groups was not statistically significant (p=0.076). The POAG group had higher NLR values than the control (p=0.035).
CONCLUSION: Both the POAG and the PACG groups exhibited higher platelet and PLR levels than the control. These results indicate a potential role of systemic inflammation in the pathogenesis of POAG and PACG (Tab. 4, Fig. 1, Ref. 35).

Keywords: neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte-ratio; primary open-angle glaucoma; primary angle-closure glaucoma; systemic inflammation
Published online: 04-Jan-2021
Year: 2021, Volume: 122, Issue: 1 Page From: 45, Page To: 48

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