Home HOME Neoplasma 2021 Neoplasma Vol.68, No.3, p.482–489,2021

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.68, No.3, p.482–489,2021

Title: DNA methylation patterns of SOCS1 gene in peripheral blood identifies risk loci associated with bladder cancer based on principal component analysis
Author: Hongjun Guan, Junhua Lu, Mengying Qu, Lili Meng, Yupeng Guo, Xiaoxia Li, Hongmei Shen

Abstract: Bladder cancer (BCa) is a common carcinoma of the urinary tract which occurs in the bladder mucosa. In recent years, people have recognized that epigenetic changes such as DNA methylation play important roles in the development of BCa, but the specific mechanism is unclear. In this study we detected the methylation rates in SOCS1 gene of 490 subjects (including 247 patients with BCa, and 243 healthy controls) using the MassARRAY EpiTYPER system. Principal component analysis (PCA) was conducted with the aim of identifying common underlying patterns that could explain the largest part of common variance in methylation across units. Logistic regression model was used to assess the relation of SOCS1 methylation patterns with factors related to BCa risk.
The methylation rates varied for different CpG units and were significantly difference in cases compared to controls. Six principal component factors were extracted by combining initial eigenvalue, explanatory power and Scree Plot. After adjusting for age, gender, family history of bladder cancer, smoking, and drinking, we observed that Factor 1 (OR=0.051, 95%CI: 0.015-0.178, p patterns were associated with the incidence of BCa, revealed the important DNA methylation patterns for BCa pathogenesis. Our findings provided new insights into understanding this disease and new potential targets for therapeutic intervention for BCa patients in the future.

Keywords: bladder cancer; DNA methylation; suppressor of cytokine signaling 1; principal component analysis
Published online: 14-Jan-2021
Year: 2021, Volume: 68, Issue: 3 Page From: 482, Page To: 489

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