Home HOME Neoplasma 2021 Neoplasma Vol.68, No.2, p.240–252, 2021

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ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.68, No.2, p.240–252, 2021

Title: Research progress review on long non-coding RNA in colorectal cancer
Author: JieLing Zhang, Kai Li, HuiFen Zheng, YiPing Zhu

Abstract: Colorectal cancer (CRC) is one of the most common malignancies globally, and the morbidity and mortality rates associated with it are among the highest around the world. Even great advances in colorectal cancer diagnosis and treatment technologies have not been able to increase the 5-year survival rate in this disease. Recidivation and metastasis are the main causes of death in CRC, although the underlying mechanism remains unknown. Long non-coding RNA (lncRNA) is a type of non-coding RNA that is greater than 200 nt in length. LncRNA is involved in cell proliferation, apoptosis, metastasis, and differentiation. Abnormal expression of lncRNA is reported in various diseases. Relevant studies have demonstrated that lncRNAs are capable of interacting with DNAs, RNAs, and proteins, thereby regulating the Wnt, p53, and other signaling pathways and playing an important role in the biogenesis, progression, metastasis, and drug resistance in CRC. In the present report, recent progress in the research related to lncRNAs in colorectal cancer is reviewed.

Keywords: LncRNA; colorectal cancer; diagnosis and prognosis; biomarkers; drug resistance
Published online: 14-Jan-2021
Year: 2021, Volume: 68, Issue: 2 Page From: 240, Page To: 252

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