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Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.2, p.101–110,2021
Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.2, p.101–110,2021
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Bratislava Medical Journal Vol.122, No.2, p.101–110,2021 |
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| Title: Are clarithromycin, azithromycin and their analogues effective in the treatment of COVID19? | ||
| Author: M. A. Gedikli, B. Tuzun, A. Aktas, K. Sayin, H. Ataseven | ||
| Abstract: BACKGROUND: SARS-CoV-2, which started in Wuhan and later affected the whole world, is the most important disease of the world today. Many ways to inhibit SARS-CoV-2 virus are sought to prevent the spread of this virus. Azithromycin and clarithromycin are considered for the treatment of the SARS-CoV-2 virus, which has a high similarity to previous colonic diseases. AIM: We aimed to determine whether azithromycin and clarithromycin, the RNA-dependent RNA polymerase protein inhibitor used in the treatment of COVID-19, is effective against SARS Cov-2 in silico. RESULTS AND CONCLUSION: The 503 analogues of azithromycin and clarithromycin were studied to target SARS-CoV-2 the RNA-dependent RNA polymerase protein inhibition. Maestro program was used to compare the inhibition activities of these analogues. A detailed comparison was made using the numerical value of many parameters obtained. ADME / T properties were then examined to determine the effects and reactions of analogues on human metabolism. In this study, the SARS-CoV2 virus is 6NUR and 6NUS, which is the RNA-dependent RNA polymerase protein. Among these proteins, the best inhibitor among the 503 analogues according to the docking score parameter was 9851445 with a great difference. This analogue was an analogue of azithromycin (Tab. 3, Fig. 6, Ref. 58). |
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| Keywords: SARS-CoV-2, RNA-dependent RNA polymerase, Azithromycin, Clarithromycin, COVID19 | ||
| Published online: 26-Jan-2021 | ||
| Year: 2021, Volume: 122, Issue: 2 | Page From: 101, Page To: 110 | |
| doi:10.4149/BLL_2021_015 |
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