Home Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.2, p.116–119,2021

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.122, No.2, p.116–119,2021

Title: Does mean platelet volume/lymphocyte count ratio associate with frailty in type 2 diabetes mellitus?
Author: S. Bilgin, G. Aktas, G. Kahveci, B. M. Atak Tel, O. Kurtkulagi, T. Taslamacioglu Duman

Abstract: OBJECTIVES: Frailty is a common problem in patients with type 2 diabetes mellitus (T2DM). It is considered to be associated with inflammation. Novel markers derived from hemogram, such as neutrophil/lymphocyte ratio (NLR) and mean platelet volume/lymphocyte ratio (MPVLR), are proposed as inflammatory markers. In present study, we aimed to compare NLR and MPVLR levels of frail patients with T2DM to non‑frail diabetic subjects.
METHODS: Diabetic subjects were grouped in frail and non-frail groups according to the Edmonton Frail Scale. General characteristics and laboratory data of the frail and non-frail groups were compared.
RESULTS: The MPVLR of the frail (3.9 [1.4–13.2] %) group was significantly higher than that of the non-frail (3.4 [1.5–6.9] %) group (p = 0.02). MPVLR was positively and significantly correlated with Edmonton Frail Scale score (r = 0.21, p = 0.03). A MPVLR level greater than 3.41 % has 71 % sensitivity and 51 % specifity in predicting frailty.
CONCLUSION: We suggest that elevated MPVLR could be a finding that marks frailty in diabetic subjects. Inexpensive and easy‑to‑assess nature of the MPVLR may be useful in predicting frailty in type 2 diabetic population (Tab. 2, Fig. 1, Ref. 32).

Keywords: mean platelet volume/lymphocyte ratio, frailty, inflammation, type 2 diabetes mellitus
Published online: 26-Jan-2021
Year: 2021, Volume: 122, Issue: 2 Page From: 116, Page To: 119

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