Home Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.3, p.179–183,2021

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.122, No.3, p.179–183,2021

Title: Association of multispecific red blood cell alloimmunization with HLA-Class II variants is related to Rh phenotypes
Author: A. Maluskova, F. Mrazek, R. Kozelska, M. Koristka, Z. Cermakova

Abstract: AIM: It remains unclear, why only some patients form alloantibodies against foreign RBC antigens. Transfusion of red blood cell (RBC) products and pregnancy are the most relevant causes of immunization against RBC alloantigens. Here we investigated the relationship between RBC alloantibodies, Rh phenotype, and HLA phenotype among patients with multiple RBC alloantibodies
METHODS: In a group of 124 multi-responders ‒ including both pregnant women and transplant recipients ‒ we analysed the distribution of HLA-Class II variants in subgroups of multi-responders to RBC alloantigens according to their Rh status.
RESULTS: As expected, the RhD-negative phenotype was overrepresented in our alloimmunized group (49.2 %) compared to in the general population. Importantly, HLA-DRB1*15 carriers were significantly overrepresented among D-negative multi-responders compared to D-positive multi-responders (Pc = 0.045). Furthermore, the linked HLA-DRB1*13, HLA-DQB1*06, and HLA-DQA1*01 variants were more frequent in individuals with the DCCee phenotype than in other RhD-positive phenotypes.
CONCLUSION: Our present findings showed that RBC multispecific alloimmunization was associated with particular HLA-Class II variants based on Rh status (Tab. 3, Ref. 22).

Keywords: HLA, red blood cell (RBC) antigens and antibodies (Abs), Rh phenotypes, transfusion therapy
Published online: 12-Feb-2021
Year: 2021, Volume: 122, Issue: 3 Page From: 179, Page To: 183
doi:10.4149/BLL_2021_028


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