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Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.3, p.200–205,2021
Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.3, p.200–205,2021
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Bratislava Medical Journal Vol.122, No.3, p.200–205,2021 |
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| Title: The relationship between vitamin D and the severity of COVID-19 | ||
| Author: N. Basaran, M. Adas, Y. Gokden, N. Turgut, T. Yildirmak, G. Guntas | ||
| Abstract: AIM: Vitamin D, which has immunomodulatory effect, can reduce risk of infections and concentrations of pro-inflammatory cytokines. The aim of this study was to investigate the relationship between the levels of vitamin D and severity of COVID-19. METHODS: A total of 204 patients with COVID-19 disease were enrolled in the study. All patients had viral pneumonia, which was confirmed with chest computer tomography. All cases were divided in two groups- mild (outpatients); and serious (inpatients)- according to their clinical and laboratory data. Serum vitamin D levels were measured by chemiluminescence method. RESULTS: Vitamin D deficiency was found in 41.7 % (n = 85) of cases and insufficiency was found in 46.0 % (n = 94), while in 12.3 % (n = 25) of cases normal vitamin D levels were found. The odds of having a serious clinical outcome were increased for vitamin D insufficiency patients 5.604 times (%95 CI:0.633–49.584) and for vitamin D deficiency patients 38.095 times (%95 CI:2.965–489.50) for each standard deviation decrease in serum 25(OH)D. CONCLUSION: Adequate levels of vitamin D could suppress inflammation and reduce the severity of COVID-19. Vitamin D supplementation may have an important role in decreasing the impact of the pandemic (Tab. 5, Fig. 2, Ref. 27). |
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| Keywords: COVID-19, CRP, d-dimer, ferritin, vitamin D | ||
| Published online: 12-Feb-2021 | ||
| Year: 2021, Volume: 122, Issue: 3 | Page From: 200, Page To: 205 | |
| doi:10.4149/BLL_2021_034 |
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