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Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.6, p.424–431,2021
Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.6, p.424–431,2021
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Bratislava Medical Journal Vol.122, No.6, p.424–431,2021 |
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| Title: Acute effect of thymoquinone on action potential and ionic currents of rat cardiac myocytes | ||
| Author: T. Mercan, B. E. Yamasan, O. Erkan, S. Ozdemir | ||
| Abstract: OBJECTIVES: This study aims to investigate the acute effects of thymoquinone (TQ) which has been suggested to be a cardioprotective agent, on ventricular myocytes. METHODS: Freshly isolated rat ventricular myocytes were exposed to TQ and using standard whole-cell patch-clamp technique action potential (AP), sodium current (INa), L-type calcium current (ICaL) and transient outward potassium current (Ito) were measured. RESULTS: TQ prolonged the duration of AP and decreased the peak value compared to that of control myocytes. Consistently, it inhibited INa in a concentration-dependent manner and shifted the channel kinetics to more hyperpolarized voltages. Besides, TQ not only inhibited Ito and ICaL but also significantly attenuated the isoproterenol-induced increase in ICaL. CONCLUSION: The effect of TQ on cardiomyocytes has been demonstrated for the first time. TQ changes AP morphology along with ionic currents and alleviates β-adrenergic response in adult ventricular myocytes. These results indicate that TQ may be considered as a therapeutic agent in cases such as diabetic cardiomyopathy and cardiac hypertrophy, wherein the β-adrenergic system is over-activated (Tab. 2, Fig. 6, Ref. 30). |
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| Keywords: thymoquinone, action potential, ionic currents, β-adrenergic response, ventricular myocytes | ||
| Published online: 18-May-2021 | ||
| Year: 2021, Volume: 122, Issue: 6 | Page From: 424, Page To: 431 | |
| doi:10.4149/BLL_2021_070 |
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