Home HOME Neoplasma 2021 Neoplasma Vol.68, No.4, p.780–787, 2021

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ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.68, No.4, p.780–787, 2021

Title: Circ-sirt1 inhibits growth and invasion of gastric cancer by sponging miR-132-3p/miR-212-3p and upregulating sirt1 expression
Author: Qing-Ke Li, Yan-Kun Liu, Jing-Wu Li, Yuan-Ting Liu, Yu-Feng Li, Bing-Hui Li

Abstract: circRNAs have been considered as a rising factor in cancers. However, the roles and mechanisms of circ-sirt1 in gastric cancer (GC) remain largely unknown. In this study, we found that the expressions of sirt1 and circ-sirt1 are decreased in tissues or serums of GC patients by real-time quantitative PCR (RT-qPCR). The expressions of miR-132-3p/miR-212-3p showed an opposite tendency in these samples. The co-transfection of miR-132-3p/miR-212-3p mimics counteracted the enhancement of sirt1 expression induced by circ-sirt1. The results of cell colony-formation assay and Transwell assays demonstrated that the proliferation, migration, and invasion activities of BGC-823 cells were inhibited by circ-sirt1 overexpression or miR-132-3p/miR-212-3p knockdown, respectively. The xenograft tumor model result indicated that the circ-sirt1 overexpression suppressed the tumor growth of BGC-823 cells. The regulation of miR-132-3p/miR-212-3p between circ-sirt1 and sirt1 was verified in the mice tumor tissues. Thus, circ-sirt1 inhibited tumor growth and invasion probably by sponging miR-132-3p/miR-212-3p and upregulating sirt1 expression in GC. These findings may provide a theoretical basis for the classification of GC and a novel therapeutic target for GC patients.

Keywords: gastric cancer; circ-sirt1; sirt1; miR-132-3p; miR-212-3p; growth; invasion
Published online: 26-May-2021
Year: 2021, Volume: 68, Issue: 4 Page From: 780, Page To: 787

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