Home 
General Physiology and Biophysics 2021 General Physiology and Biophysics Vol.40, No.3, p.161–171, 2021
General Physiology and Biophysics 2021 General Physiology and Biophysics Vol.40, No.3, p.161–171, 2021
Journal info
Aims and Scope |
||
Select Journal
Journals
Acta Virologica Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Neoplasma Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
General Physiology and Biophysics Vol.40, No.3, p.161–171, 2021 |
||
| Title: Protective effect of Apelin/APJ system on lipopolysaccharide-related cardiac dysfunction | ||
| Author: Junli Hu, Shuhua Huo, Shiying Dou, Wei Jiang, Yongjun Li | ||
| Abstract: At present, the pathogenesis of sepsis-induced myocardial dysfunction (SIMD) is not completely clear and effective treatment measures are lacking. Apelin is an endogenous ligand of the angiotensin like G protein coupled receptor APJ and a cardiovascular peptide with multiple functions. Our aim is to analyze the protective effect and mechanism of Apelin/APJ system on lipopolysaccharide (LPS)-induced myocardial dysfunction. One hour before LPS treatment, apelin-13 or an APJ antagonist [Ala]-apelin-13 (F13A) was given for pre-intervention to observe the effect of apelin-13 on cardiac ultrasound, pathological changes and inflammatory factors in LPS-treated mice. Another part of the mice was treated with apelin-13 or apelin-13 combined with F13A one hour after LPS treatment. The results showed that apelin-13 injection significantly reversed the decrease of ejection fraction and the increase of inflammatory factors induced by LPS in mice. Endogenous apelin may have protective effect on SIMD induced by LPS. Exogenous administration of apelin may inhibit LPS-induced inflammation, apoptosis and increase autophagy through TLR4/ERK1/2/NF-κB pathway. |
||
| Keywords: SIMD — Apelin — APJ — Protective effect | ||
| Published online: 09-Jun-2021 | ||
| Year: 2021, Volume: 40, Issue: 3 | Page From: 161, Page To: 171 | |
| doi:10.4149/gpb_2021006 |
||
|
|
 download file |
|