Home Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.7, p.469–473,2021

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.122, No.7, p.469–473,2021

Title: Insulin-like growth factor (IGF) system and hormonal-metabolic profile in women with polycystic ovary syndrome
Author: I. Lazurova, J. Figurova, Z. Lazurova, I. Dravecka, J. Maslankova, M. Marekova

Abstract: AIM of the study was to compare serum levels of IGF-1, IGF-2 and insulin‑like growth factor‑binding protein 3 (IGFBP-3) among non‑obese and obese PCOS women, and to assess their relationship to metabolic and hormonal parameters.
METHODS: The study included 64 women diagnosed with PCOS (age 28.9 ± 5 years); 30 of them with BMI > 27 and 34 with BMI lower than 27. All subjects were examined for parameters of glucose and lipid metabolism, steroid hormones and serum IGF-1, IGF-2 and IGFBP-3 levels.
RESULTS: No significant differences in serum IGFBP-3 (p=0.534), IGF-1 (p=0.29) and IGF-2 (p=0.56) between two groups have been detected. IGFBP-3 was in positive correlation with total cholesterol (p=0.026), LDL cholesterol (p=0.03) and triacylglycerols (p=0.022). IGF-1 were negatively correlated with insulin (p=0.022), HOMA IR (p=0.033), triacylglycerols (p=0.0196) and waist circumference (p=0.049).

A positive correlation was detected between IGF-1 and HDL cholesterol (p=0.025). No significant relationship was observed between IGF-1 and steroid hormones.
CONCLUSION: Serum levels of IGF-1, IGF-2 and IGFBP-3 in obese PCOS women do not differ from those detected in non‑obese PCOS women. IGF-1 negatively correlated with metabolic parameters, indicating that lower IGF-1 may represent an important predictor of metabolic syndrome (MS) in PCOS women. All peptides seem to have little effect on ovarian steroidogenesis in PCOS (Tab. 1, Fig. 1, Ref. 30).

Keywords: polycystic ovary syndrome, metabolic syndrome, IGF-1, IGF-2, IGFBP-3
Published online: 23-Jun-2021
Year: 2021, Volume: 122, Issue: 7 Page From: 469, Page To: 473

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