Home 
Acta Virologica Ahead of print Acta Virologica Vol.65, No.3, p.245-253, 2021
Acta Virologica Ahead of print Acta Virologica Vol.65, No.3, p.245-253, 2021
Journal info
|
||
Select Journal
Webshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Acta Virologica Vol.65, No.3, p.245-253, 2021 |
||
| Title: T cell responses in symptomatic moderate patients with pandemic 2009 H1N1 influenza A virus infection | ||
| Author: Dimpu Gogoi, Dipankar Biswas, Biswajyoti Borkakoty, Mousumi Dutta | ||
| Abstract: The response of the host immune system should be appropriate to fight against pandemic 2009 H1N1 (pH1N1) influenza A virus without causing damage to its self. T cells play an indispensable role in the fight against the virus, but have the potential to cause host immunopathological changes. A better understanding of the immunoregulation that occurs during pH1N1 infection is necessary for preventing severity of the disease. In this study, we found that a significantly higher percentage of Vδ1+ T cells and increased expression of activation markers in total T cells in patients with moderate pH1N1 infection could lead to its efficient fight against the virus. On the other hand, the percentages of total and CD4+ T cells were decreased along with an increased expression of exhaustion marker-Tim-3 on T cells that might suppress excessive T cell responses in the host. This tuning of T cell responses might be necessary in efficient combat against pH1N1 virus, without aggravating T cell mediated immunopathology in patients with moderate pH1N1-infection. |
||
| Keywords: pH1N1; T cells; activation; exhaustion; Tim-3 | ||
| Published online: 23-Sep-2021 | ||
| Year: 2021, Volume: 65, Issue: 3 | Page From: 245, Page To: 253 | |
| doi:10.4149/av_2021_301 |
||
|
|
 download file |
|