Home HOME Acta Virologica 2021 Acta Virologica Vol.65, No.3, p.245-253, 2021

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Acta Virologica Vol.65, No.3, p.245-253, 2021

Title: T cell responses in symptomatic moderate patients with pandemic 2009 H1N1 influenza A virus infection
Author: Dimpu Gogoi, Dipankar Biswas, Biswajyoti Borkakoty, Mousumi Dutta

Abstract: The response of the host immune system should be appropriate to fight against pandemic 2009 H1N1 (pH1N1) influenza A virus without causing damage to its self. T cells play an indispensable role in the fight against the virus, but have the potential to cause host immunopathological changes. A better understanding of the immunoregulation that occurs during pH1N1 infection is necessary for preventing severity of the disease. In this study, we found that a significantly higher percentage of Vδ1+ T cells and increased expression of activation markers in total T cells in patients with moderate pH1N1 infection could lead to its efficient fight against the virus. On the other hand, the percentages of total and CD4+ T cells were decreased along with an increased expression of exhaustion marker-Tim-3 on T cells that might suppress excessive T cell responses in the host. This tuning of T cell responses might be necessary in efficient combat against pH1N1 virus, without aggravating T cell mediated immunopathology in patients with moderate pH1N1-infection.

Keywords: pH1N1; T cells; activation; exhaustion; Tim-3
Published online: 23-Sep-2021
Year: 2021, Volume: 65, Issue: 3 Page From: 245, Page To: 253
doi:10.4149/av_2021_301
Price: 21.60 €






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