Home Acta Virologica 2021 Acta Virologica Vol.65, No.3, p.254-263, 2021

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ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.65, No.3, p.254-263, 2021

Title: Lupeol impairs herpes simplex virus type 1 replication by inhibiting the promoter activity of the viral immediate early gene α0
Author: Ju Ye, Zhaoyang Wang, Jiaoyan Jia, Feng Li, Yiliang Wang, Yuzhou Jiang, Yifei Wang, Zhe Ren, Hanlin Pu

Abstract: Herpes simplex virus type 1 (HSV-1) is an important human pathogenic virus. It is urgent to develop novel antiviral targets because of the limited treatment options and the emergence of drug resistant strains. In this study, we tested the antiviral activity of lupeol, a triterpenoid compound, against HSV-1 and acyclovir (ACV) resistant strains. Lupeol significantly inhibited HSV-1 (F strain) and ACV-resistant strains including HSV-1/106, HSV-1/153, and HSV-1/Blue. Lupeol activity of the HSV-1α0 and α4 promoters, therefore down regulating the expression of the α0, α4, and α27 genes. Collectively, lupeol showed strong antiviral activity against HSV-1 and ACV-resistant strains, and could be a promising therapeutic candidate for HSV-1 pathogenesis.

Keywords: herpes simplex virus 1; lupeol; ACV-resistant strains; promoter
Published online: 24-Sep-2021
Year: 2021, Volume: 65, Issue: 3 Page From: 254, Page To: 263
doi:10.4149/av_2021_302
Price: 24.00 €






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