Home HOME Acta Virologica 2021 Acta Virologica Vol.65, No.3, p.307-312, 2021

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ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.65, No.3, p.307-312, 2021

Title: The newborns Torque teno virus dynamics depending on the term, feeding type and maternal viral load
Author: Elena A. Lolomadze, Anna V. Degtyareva, Denis V. Rebrikov

Abstract: The first weeks of life are extremely important for the development of the immunity-virome interaction that affects human health in adulthood. In this study we analyzed Torque teno virus (TTV) dynamics during the first weeks of life in the full-term/premature infants in relation with the maternal TTV load and the type of feeding. 152 infants aged 1–14 weeks (63 full-term and 89 premature) and 33 mother-child pairs were analyzed for the whole blood TTV load by qPCR with test sensitivity of 1000 viral copies/ml. 50 infants were retested (at 2–11 time points) for TTV dynamics data. All one-week babies (n = 71) from TTV-positive mothers were TTV-negative, consistently with the previous findings of the lack of transplacental transmission of the virus. TTV was not detectable in newborns under two weeks of age. Most infants are TTV-positive by 14 weeks of age. Whole blood TTV load does not show significant correlation with full-term/prematurity, maternal TTV load, or feeding type.

Keywords: Torque teno virus; transfusion-transmitted virus; commensal virus; TTV; viral load dynamics; TORCH infections; full-term and premature babies; breastfeeding; virome
Published online: 24-Sep-2021
Year: 2021, Volume: 65, Issue: 3 Page From: 307, Page To: 312
doi:10.4149/av_2021_306
Price: 14.40 €






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