Home General Physiology and Biophysics 2021 General Physiology and Biophysics Vol.40, No.4, p.257–274

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.40, No.4, p.257–274

Title: Identification of an autophagy-related 10-lncRNA-mRNA signature for distinguishing glioblastoma multiforme from lower‑grade glioma and prognosis prediction
Author: Bo Wei, Le Wang, Jingwei Zhao

Abstract: Autophagy may provide the source of nutrients for tumor cells. We aim to develop an autophagy-related signature to predict the progression from lower-grade gliomas (LGG) to glioblastoma multiforme (GBM) and prognosis. Totally, 686 differentially expressed genes (DEGs) and 73 long non-coding RNAs (DELs) were identified between GBM and LGG samples from the Chinese Glioma Genome Atlas (CGGA). Of them, 131 DEGs were intersected with autophagy genes from the Human Autophagy Database; while 54 DELs co-expressed with autophagy-related DEGs. Ten autophagy-related genes were associated with overall survival and could distinguish GBM from LGG, with the accuracy of 0.891 using CGGA dataset and 0.790 using The Cancer Genome Atlas (TCGA) dataset. The risk score was established based on these 10 genes. Patients with higher risk score were at an increased risk of developing GBM (49.7% vs. 21.3%; p 

Keywords: Glioblastoma — Lower-grade glioma — Nomogram — Prognostic signature — Autophagy-related genes — Autophagy-related lncRNAs
Published online: 01-Aug-2021
Year: 2021, Volume: 40, Issue: 4 Page From: 257, Page To: 274

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