Home General Physiology and Biophysics 2021 General Physiology and Biophysics Vol.40, No.4, p.307–315

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.40, No.4, p.307–315

Title: IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Author: Karolina Cseri, Péter Szentesi, László Csernoch

Abstract: Skeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RAW macrophage culture is used as the culture medium of C2C12 cells or vice versa. Pravastatin, known to induce myopathy, also stimulates IL-6 production in monocultured C2C12 cells and elevates IL-6 concentration in the culture medium of the co-cultures. These results indicate an intricate interaction between skeletal muscle and macrophages in inflammation related to IL-6 production.

Keywords: Skeletal muscle — Macrophages — Co-culture — IL-6 — Pravastatin
Published online: 01-Aug-2021
Year: 2021, Volume: 40, Issue: 4 Page From: 307, Page To: 315

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