Home HOME Acta Virologica Ahead of print Acta Virologica Vol.65, No.3, p.324-329, 2021

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.65, No.3, p.324-329, 2021

Title: Conserved broad HIV-1 Gag-specific responses associated with low viral load and high CD4+ T cell nadir and preserved HAART regimen
Author: Luciano Rodrigo Lopes, Jorge Simão do Rosário Casseb, Alberto José da Silva Duarte

Abstract: Broad human immunodeficiency virus type 1 (HIV-1) Gag-specific cellular responses can control viremia and provide slow progression to Acquired immunodeficiency syndrome (AIDS). In this study, we evaluate multiple HIV-1 Gag-specific lymphoproliferative responses and find their connection with cluster of differentiation 4 (CD4)+ T cell count and viral load from chronically HIV-1-infected patients. We further search for the correlation between multiple Gag-specific lymphoproliferative responses and changes in highly active antiretroviral therapy (HAART) regimen. We found correlation between Gag-specific responses and higher CD4+ T cells nadir and low HIV-1 viral load. Additionally, we observed that HIV-1-infected subjects did not need to change HAART regimen, when multiple Gag responses are present. We concluded that the start of HAART when CD4+ T cell nadir is the highest as possible may promote Gag-specific cellular responses conservation. Multiple Gag responses must be important to suppress HIV-1 replication. Preserved Gag-specific responses reduce HIV-1 viral load and are associated with stability of HAART regimen.

Keywords: HIV-1; Gag; lymphoproliferation; viral load; HAART
Published online: 06-Aug-2021
Year: 2021, Volume: 65, Issue: 3 Page From: 324, Page To: 329
doi:10.4149/av_2021_311


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