Home Acta Virologica Ahead of print Acta Virologica Vol.65, No.4, p.333-338, 2021

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

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Acta Virologica Vol.65, No.4, p.333-338, 2021

Title: Natural immune response and protection from SARS-CoV-2 reinfection
Author: Katia Margiotti , Marco Fabiani, Alvaro Mesoraca, Claudio Giorlandino

Abstract: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the associated disease Coronavirus disease 2019 (COVID-19) continues to spread throughout the world, causing millions of infections and dead. One major question in predicting the course of the COVID-19 pandemic is how well and how long the immune response protects the host from reinfection. Although more studies are needed, evidence suggests that virus-specific B cell response in people with SARS-CoV-2 infection is rapidly generated and seems to be more reliable marker of long-lasting humoral responses than serum antibodies. Here we reviewed all related major studies of immune response to SARS-CoV-2 virus to better understand the natural protection against the virus, and the risk of reinfection. The ability of our community to eradicate this virus will mostly depend on our knowledge of the immune response, critical not only for vaccine development and distribution but also for therapeutic options.

Keywords: SARS-CoV-2 virus reinfection; humoral immune response; SARS-CoV-2 virus variants; vaccination
Published online: 06-Aug-2021
Year: 2021, Volume: 65, Issue: 4 Page From: 333, Page To: 338

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