Home HOME Neoplasma 2021 Neoplasma Vol.68, No.5, p.1015–1022, 2021

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ISSN 0028-2685
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Neoplasma Vol.68, No.5, p.1015–1022, 2021

Title: Hypoxia facilitates the proliferation of colorectal cancer cells by inducing cancer-associated fibroblast-derived IL6
Author: Ying Xu, Rong Kuai, Yi-Min Chu, Lu Zhou, Hai-Qin Zhang, Ji Li

Abstract: Colorectal cancer (CRC) is the most common malignancy worldwide, and its underlying molecular mechanisms remain largely unexplored. Accumulating evidences indicate cancer-associated fibroblasts (CAFs), abundant stromal cell population in the tumor microenvironment, play a key role in tumor development. Herein, we have successfully isolated CAFs and paired normal fibroblasts (NFs) from colorectal cancer tissues (n = 10). By using a multiplex cytokine profiling assay, we have identified IL-6 as a major cytokine released by CAFs. Co-culturing of CAFs with CRC cell lines HCT116 or SW480 increases IL-6 release, and the secretion by CAFs can be further enhanced under hypoxia. By using the CCK-8 assay, we have found that HCT116 or SW480 cells treated with culture medium from CAFs, IL-6, or hypoxia showed a significant cell growth compared to control cells (P

Keywords: colorectal cancer; cancer associated fibroblast; IL-6; cell proliferation
Published online: 10-Aug-2021
Year: 2021, Volume: 68, Issue: 5 Page From: 1015, Page To: 1022

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