Home HOME Neoplasma 2021 Neoplasma Vol.68, No.5, p.1023–1032, 2021

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Neoplasma Vol.68, No.5, p.1023–1032, 2021

Title: Co-expression of CD24 and Hsp70 as a prognostic biomarker for lung cancer
Author: Xiao-Juan Qiao, Yan Gu, Hua Du, Zhi-Wei Xing, Bu-Huan Ma, Wei-Ting Sun, Jing-Feng Yu, Cai-Xia Liu

Abstract: Lung cancer is one of the most common malignant neoplasms worldwide. CD24 is a marker of tumor stem cells that plays an important role in tumorigenesis. Hsp70 is an important molecular chaperone. However, the co-expression and interaction of CD24 and Hsp70, as well as the significance for the prognosis of lung cancer are still unclear. The expression levels of CD24 and Hsp70 were detected by immunohistochemistry and their correlation was analyzed. The expression levels of CD24 mRNA and protein were examined using qRT-PCR and western blotting in SPCA1, A549, H1975, and H1650 cell lines. A CD24-overexpressing cell model was established. The interaction between CD24 and Hsp70 was verified by co-immunoprecipitation and western blotting. CD24 and Hsp70 expression were significantly higher in lung cancer tissues than in adjacent tissues (CD24: P = 0.008; Hsp70: P vasion, metastasis, and poor survival. Hsp70 may regulate CD24 expression. Co-expression of CD24 and Hsp70 may be a prognostic biomarker for lung cancer.

Keywords: CD24; Hsp70; lung cancer; interaction
Published online: 24-Aug-2021
Year: 2021, Volume: 68, Issue: 5 Page From: 1023, Page To: 1032

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