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Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.9, p.626–630,2021
Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.9, p.626–630,2021
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Bratislava Medical Journal Vol.122, No.9, p.626–630,2021 |
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| Title: Comparison of standard prophylactic and preemptive therapeutic low molecular weight heparin treatments in hospitalized patients with COVID-19 | ||
| Author: B. Copur, S. Surme, U. Sayili, G. Tuncer, E. Zerdali, M. Yazla, I. Y. Nakir, A. Buyukyazgan, A. R. Kurt-Cinar, H. Balli, Y. Kurekci, F. Pehlivanoglu, G. Sengoz | ||
| Abstract: NTRODUCTION: Anticoagulant treatment approach in patients with COVID-19 is not well studied and not standardized. We aimed to compare the effects of standard prophylactic and pre-emptive therapeutic Low-Molecular-weight Heparin (LMWH) treatment approaches on mortality in patients with COVID-19. PATIENTS AND METHODS: This retrospective and single-centre study includes patients aged ≥ 18 years, who were diagnosed with COVID-19 and treated with LMWH during the hospital stay. Therapeutic dose of LMWH was defined as 1 mg/kg subcutaneously twice daily and prophylactic dose of LMWH was defined as 40 mg subcutaneously once daily. RESULTS: Among the 336 patients diagnosed with COVID-19 pneumonia, 115 patients, who received LMWH were included in the study. The mean age was 58.6 ± 13.3 and 58 (50.4 %) of the patients were male. Sixty-nine (60 %) of the patients were treated with prophylactic and 46 (40 %) therapeutic LMWH.In-hospital mortality was not different between patients treated therapeutic LMWH and prophylactic LMWH by the multivariate regression analysis (OR=2.187, 95% CI 0.484–9.880, p=0.309) and the propensity score modelling (OR=1.586, 95% CI 0.400–6.289, p=0.512.) CONCLUSION: Clinicians should consider the potential risks and benefits of standard prophylactic and pre-emptive therapeutic LMWH. Therefore, anticoagulant therapy should be individualized in patients with COVID-19 (Tab. 3, Ref. 28). |
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| Keywords: anticoagulant therapy, COVID-19, Low-molecular-weight heparin (LMWH), mortality, outcome | ||
| Published online: 31-Aug-2021 | ||
| Year: 2021, Volume: 122, Issue: 9 | Page From: 626, Page To: 630 | |
| doi:10.4149/BLL_2021_100 |
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