Home HOME Neoplasma 2021 Neoplasma Vol.68, No.5, p.907–916, 2021

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.68, No.5, p.907–916, 2021

Title: The role of corticotropin-releasing hormone (CRH) family in tumor
Author: Su-Qin Yi, Jia-Xing An, Cheng-Cheng Liao, Sha Lei, Hai Jin, Bi-Guang Tuo

Abstract: The corticotropin-releasing hormone (CRH) family is widely distributed among the central nervous system and peripheral tissues, such as the digestive, cardiovascular, immune, reproductive, endocrine systems. The CRH family members are widely involved in the regulation of human cell biological processes, immune response, and regulation of inflammatory processes that can affect the occurrence and development of tumors. At present, CRH family members and their receptors can be detected in many tumor tissues, and some people think that members of the CRH family may be potential tumor treatment targets as they can affect cellular processes, such as proliferation, migration, invasion, and apoptosis. However currently, there is no systematic introduction to the relationship between the CRH family and various tumors. This review introduces the molecular regulation of the CRH family in tumor formation and seeks further targeted therapy.

Keywords: CRH family; cancer; targeted therapy; mechanism
Published online: 17-Sep-2021
Year: 2021, Volume: 68, Issue: 5 Page From: 907, Page To: 916

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