Home Neoplasma 2021 Neoplasma Vol.68, No.6, p.1157–1168, 2021

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.68, No.6, p.1157–1168, 2021

Title: microRNA-10a-5p overexpression suppresses malignancy of colon cancer by regulating human liver cancer fibroblasts
Author: Xuan Zheng, Jing-Wu Li, Yan-Kun Liu, Yi-Fu Ma, Jian-Hui Gan, Su-Gui Han, Jian Wang, Zhao-Yuan Wan, Jun Zhang, Yan Liu, Yu-Feng Li, Guang-Ling Zhang

Abstract: The crosstalk between tumor and stroma plays a critical role in cancer metastasis. However, the function of miR-10a-5p on liver fibroblasts in the metastatic microenvironment of colon cancer (CC) and the effect of activated fibroblasts on CC cells are still unclear. In our study, miR-10a-5p overexpression inhibited the proliferation, migration, and IL-6/IL-8 level of LX-2 and human liver cancer fibroblasts (HLCFs) cells. Moreover, miR-10a-5p had lower expression in HLCFs than in human liver normal fibroblasts (HLNFs). The conditioned medium (CM) from LX-2 cells with miR-10a-5p overexpression and HLNFs could inhibit the invasion, migration, and stemness of CC SW480 cells, whereas HLCFs CM could promote these malignant phenotypes of SW480 cells. The present study illustrates the effect of miR-10a-5p on the liver fibroblasts and the altered liver fibroblasts in the microenvironment on CC cells induced by miR-10a-5p, which may aid the understanding of the mechanisms underlying CC liver metastasis.

Keywords: colon cancer liver metastasis; fibroblasts; miR-10a-5p; tumor microenvironment
Published online: 17-Sep-2021
Year: 2021, Volume: 68, Issue: 6 Page From: 1157, Page To: 1168

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