Home General Physiology and Biophysics 2021 General Physiology and Biophysics Vol.40, No.5, p. 397–407, 2021

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.40, No.5, p. 397–407, 2021

Title: Anti-leukaemia effects of leonurine in vitro and in vivo
Author: Qiang Zhuang, Lina Ruan, Ting Jin, Xiangkuo Zheng, Zhenlin Jin
Abstract: The present study was conducted to explore the anti-acute myeloid leukaemia (AML) effects of leonurine. HL-60 and U-937 cells were used to assess the antileukaemia effect of leonurine in vitro, and HL-60 and U-937 xenograft nude mice were used to evaluate its antitumour effect in vivo. Leonurine inhibited the proliferation of HL-60 and U-937 cells in a time- and dose-dependent manner. Moreover, leonurine therapy prevented the growth of tumours in both xenograft animal models. Leonurine could induce apoptosis in HL-60 and U-937 cells. The cytotoxic effects of leonurine on HL-60 and U-937 cells were associated with an increased ratio of Bax/Bcl-2, activation of caspase-3, caspase-8 and caspase-9, and increased expression of cytochrome c in the cytoplasm. Leonurine inhibited activation of the PI3K/Akt pathway in HL-60 and U-937 cells by lowering the phosphorylation levels of PI3K and Akt. Our results indicate that leonurine is a potential anti-AML agent, and this activity may be associated with its repression of the phosphorylation of PI3K and Akt.
Keywords: Leonurine — Acute myeloid leukaemia — PI3K — Akt — HL-60 — U-937
Published online: 27-Sep-2021
Year: 2021, Volume: 40, Issue: 5 Page From: 397, Page To: 407
doi:10.4149/gpb_2021018


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