Home Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.10, p.708–714,2021

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.122, No.10, p.708–714,2021

Title: Magnetic resonance spectroscopy – its added value in brain glioma multiparametric assessment
Author: M. Rudnay, I. Waczulikova, A. Bullova, G. Rjaskova, M. Chorvath, M. Jezberova, V. Lehotska
Abstract: OBJECTIVE: In this study, we analysed the results of magnetic resonance spectroscopy (MRS) in the patients with gliomas, including the error rate, MRS parameters variability, correlations with gene mutations and overall usefulness for clinical practice.
MATERIAL AND METHODS: Eighty patients with glial tumours were examined by multiparametric MRI completed with single voxel MRS, as one group, then as two separate groups according to progression of the disease after the initial surgery. The error rate between the groups, MRS parameters variability, hazard ratios and correlations between metabolites, genetic markers and tumour grade were all analysed.
RESULTS: Variability in Cho/Cr(h) was significantly higher in the group with a disease progression (p = 0.044). In the patients with a stable disease, strong significant negative correlations between Cho/Cr and Cho/NAA with p53 mutation (–0.945 and –0.812 respectively, p < 0.05) and between Cho/Cr and IDH1, 2 mutation (-0.796, p < 0.05) were found. In the patients with tumour progression, a significant positive correlation of NAA/Cr with 1p19q codeletion (0.486, p < 0.05) and of Cho/Cr and Cho/NAA values with p53 mutation (0.477 and 0.416, p < 0.05) were identified. Tumour grade positively correlated with Cho/Cr values (0.304, p = 0.02) in the whole patient group.
CONCLUSION: MRS brings an added value to multiparametric MRI evaluation of brain tumours in the patient follow-up after an initial surgery, especially in ambiguous findings (Tab. 5, Fig. 2, Ref. 29).
Keywords: glioma, MR spectroscopy, single voxel spectroscopy, choline, N-acetyl aspartate, creatine
Published online: 27-Sep-2021
Year: 2021, Volume: 122, Issue: 10 Page From: 708, Page To: 714
doi:10.4149/BLL_2021_113


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