Neoplasma Vol.68, No.6, p.1236–1244, 2021
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| Title: Inhibiting endoplasmic reticulum stress mediated-autophagy enhances the pro-apoptotic effects of resveratrol derivative in colon cancer cells |
| Author: Lei Yu, Ji-Guang Hou, Yun-Feng Li, Yin Wang, Ming Hong, Yan-Ming Yang |
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Abstract: Previous studies have demonstrated that endoplasmic reticulum stress (ERS) might play a major role in inducing cellular autophagy and apoptosis in multiple types of cancer. Herein, we observed that trans-3, 5, 4'-trimethoxystilbene (TMS) exposure facilitated apoptotic cell death and ERS-mediated autophagy in colon cancer SW480 and HCT116 cells. Interestingly, our data demonstrated that ERS was not involved in TMS-induced apoptosis. However, ERS notably induced protective autophagy in SW480 and HCT116 cells. In addition, inhibiting cellular ERS significantly improved the pro-apoptotic effects of TMS. Thus, our results indicated that TMS-mediated autophagy was dependent on ERS, while apoptotic cell death might be induced in the ERS-independent pathway after TMS treatment. Generally, inhibiting ERS-mediated autophagy can enhance the pro-apoptotic effects of TMS. TMS might be a potential therapeutic agent for colon cancer treatment.
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| Keywords: endoplasmic reticulum stress; trans-3 5 4’-trimethoxystilbene; apoptosis; autophagy; colon cancer |
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Published online: 14-Oct-2021
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| Year: 2021, Volume: 68, Issue: 6 |
Page From: 1236, Page To: 1244 |
doi:10.4149/neo_2021_210422N552
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