Home Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.11, p.763–770,2021

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.122, No.11, p.763–770,2021

Title: Point-of-care diagnosis of COVID-19 disease based on antigen tests
Author: M. Pohanka

Abstract: AIMS: This review is focused on the laboratory diagnoses of the coronavirus disease 2019 (COVID-19) by recognizing the antigen of the causative agent SARS-CoV-2 virus. Various antigen tests are available in this moment and these tests are being further developed in order to reach a better diagnostic value. The issue is reviewed in a complex view.
METHODS: In this work, a complex survey of the current literature was made. The relevant and recent papers related to antigen tests of COVID-19 are discussed and cited. Basic specifications of the antigen tests and competitive methods were also scrutinized in the current literature.
RESULTS: The survey of the current literature (years 2019 ‒ 2021) was made and diagnostic methods like lateral flow tests (lateral flow immunochromatographic assay) and various types of biosensors were specified as tools for COVID-19 diagnosis and their application to be used as a point-of-care test is considered.
CONCLUSIONS: Small hand-held assays applicable in the point-of-care conditions for diagnosis of COVID-19 by analysis of SARS-CoV-2 antigen are the means of a growing interest and these means undergo a significant development leading to the improvements of their specifications and applicability to the current praxis. Merit of the assays is discussed in this paper (Tab. 3, Fig. 2, Ref. 109).

Keywords: coronavirus disease 2019; diagnosis; enzyme-linked immunosorbent assay; immunoassay; lateral flow test; SARS-CoV-2
Published online: 21-Oct-2021
Year: 2021, Volume: 122, Issue: 11 Page From: 763, Page To: 770
doi:10.4149/BLL_2021_122


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